Lentiviral & Gammaretroviral Vector Production & Testing
End-to-end GMP viral vector manufacturing, with in-house quality control, scalable production across lentiviral and retroviral platforms, downstream‑purified material testing, and GMP‑grade plasmid sourcing. We support small‑batch and pilot runs for process qualification and early clinical needs, as well as large-scale GMP manufacturing. We offer rigorous in-process and release testing, full regulatory guidance, and multiple viral vector envelope options tailored to your needs — all under one roof to ensure speed, consistency, and compliance.
Versatile Viral Vector Production & Design
Flexible platform support for Lentiviral (LVV) and proprietary Gammaretroviral (gRV) systems
Custom envelope selection, including VSV-G, RD114 and GALV, to optimize target cell specificity
Strategic sourcing of both research-grade (RUO) and GMP-grade plasmids platforms
Benefit:
High biological flexibility with tailored vector configurations at a fraction of major license costs.
High-Yield Clinical Manufacturing Platform
Modular scale-up using multilayer cell stacks for consistent culture performance
Utilization of adherent HEK293T cell lines for robust growth, and high viral titers
Optimized transient transfection protocols for quick Phase I/II clinical batch turnaround
Benefit:
A reliable, cost-effective manufacturing path that accelerates timelines to the clinic.
Integrated cGMP QC of Viral Vector Products
In-house QC for viral safety: RCR cultivation
Sterility testing (membrane filtration), Mycoplasma (PCR), Endotoxin (LAL/PCR)
Identity and characterization: p24 ELISA particle number, stability (pH, osmolality)
Quantitative purity profiling (ELISA, PCR): Residual nuclease, host-cell protein, BSA, residual DNA (E1A, SV40, kanamycin)
Vector potency assessment: infectious titer (HEK293T with flow cytometry), absolute VCN (d/qPCR)
Benefit:
Workflow‑integrated QC that streamlines both vector release and transduction.
Advanced Downstream Processing & Testing
High-efficiency viral concentration (up to 100x) via gentle Tangential Flow Filtration (TFF)
Optimized diafiltration into tailored buffers for increased stability
Final sterilizing filtration and rigorous in-house QC testing of the final vectors
Benefit:
Maximized recovery of high-purity, sterile vectors for optimal target cell engineering.
More Ways We Help
cGMP Manufacturing and Quality Control
Cell therapy and viral vector
expertise with robust in-house QC capabilities
Lentiviral & Gammaretroviral Vector Production & Testing
Viral vectors development and manufacturing - scalable RUO & GMP grades
Analytical
Development
Analytical development include
method development,
optimization, and validation
Process Development & Tech Transfer
Scalable, optimized processes
with successful transfer from lab to GMP
Apheresis Collection
& Logistics
Seamless needle‑to‑needle coordination across 150+ EU/US legacy apheresis sites — from apheresis to patient delivery
Storage
& Distribution
Proprietary global GxP logistics, controlled storage, and cold chain management
Quality & Regulatory Support & Qualified Person Services
QP batch release under EU GMP and global compliance support
Extensive Global Heritage in Apheresis Management
SCTbio draws on a long-standing legacy of working with more than 150 qualified and trained cell-collection sites across Europe and the USA. We provide dedicated apheresis support, with rapid reactivation and site‑specific procedure alignment to secure high‑quality clinical starting material.
